Škuc Gallery has been operating in the premises at Stari trg 21 in Ljubljana since 1978 as part of the ŠKUC Cultural Centre, one of the pillars of non-governmental culture in Slovenia for over 30 years now. In these 23 years of operation, Škuc Gallery has become a prominent international art centre for exhibitions, different art events, publishing and documentation.

At the end of the '70s, the foundation of Škuc Gallery meant a counterpart to the dominant exhibition policy of the established national galleries and institutions in Slovenia. Its first artistic director was the art historian and curator Taja Vidmar Brejc and it opened with a retrospective presentation of the conceptual art group OHO.
In the eighties, Škuc Gallery under new artistic directors (Dušan Mandić, Marina Gržinić, Barbara Borčić) became the centre of (sub)culture in Slovenia, and thus even aggravated its relationship with govern-mental institutional culture. Characteristics of this period were multi-media projects; presentations of the Conceptual Art movements in Zagreb and Belgrade (Raša Todosijević, Mladen Stilinović, Goran Djordjević, for instance); and the first projects of now established Slovene artists including IRWIN, V.S.S.D., Bojan Gorenec and Marjetica Potrč.
At the turn of the last decade Tomislav Vignjević and Alenka Pirman as artistic directors were confronted with the history of the Škuc Gallery and its indisputable reputation as an elitist alternative space. The selection of annual programmes was opened to various artistic positions, and based on the following areas: first solo exhibitions of young Slovene artists; solo exhibitions (or projects outside the Gallery) by established Slovene artists; solo exhibitions (or projects outside the Gallery) by international artists; thematic and group exhibitions of guest curators, and socio-cultural documentary exhibitions. From 1996 till 2003 the artistic director was Gregor Podnar, in June 2003 Alenka Gregorič was appointed to this position.

In the last ten years, Škuc Gallery has become one of the most visited exhibition premises in Slovenia, with some 1,000 visitors on average per exhibition. The focus on regional and local developments represents a significant segment of the Gallery's programme but at the same time the involvement in the international cultural industry has become a growing part of the daily routine. We have decided to establish a closer co-operation with institutions and individuals working in the region including art centres in Austria, Croatia, Hungary and Italy, that provides a wider theoretical framework of our curatorial work. Škuc Gallery has developed into an art production centre and since 2000 it has also started to represent its artists at international art fairs.
During the last few years, the following internationally working artists were presented in the Gallery: Ingold Airlines, Rasheed Araeen, Jože Barši, Raimond Chaves, Attila Csörgő, Tacita Dean, Leif Elggren, Olafur Eliasson, Vadim Fishkin, Carl Michael von Hausswolff, IRWIN, Žiga Kariž,  Antal Lakner, Juri Leiderman, Maja Licul, M+M, Olaf Nicolai, Cesare Pietroiusti, Tadej Pogačar, Marko Peljhan, Goran Petercol, Marjetica Potrč, Mladen Stilinović, Nebojša Šerič-Šoba, Nika Špan, Apolonija Šušteršič, Elulalia Valldosera, Sislej Xhafa, and others.